Version 5.4
Homo sapiens Gene: SKAP1
Summary
InnateDB Gene IDBG-56653.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKAP1
Gene Name src kinase associated phosphoprotein 1
Synonyms HEL-S-81p; SCAP1; SKAP55
Species Homo sapiens
Ensembl Gene ENSG00000141293
Encoded Proteins
IDBP-56655
src kinase associated phosphoprotein 1
IDBP-762024
IDBP-757848
IDBP-761182
IDBP-763917
IDBP-764106
IDBP-760437
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48133440-48430275
Strand Reverse strand
Band q21.32
Transcripts
ENST00000336915 ENSP00000338171
ENST00000579336 ENSP00000464198
ENST00000584709 ENSP00000463284
ENST00000581400 ENSP00000462360
ENST00000581419 ENSP00000462437
ENST00000579476
ENST00000584924 ENSP00000464311
ENST00000583844 ENSP00000464509
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0032403 protein complex binding
GO:0042169 SH2 domain binding
Biological Process
GO:0009967 positive regulation of signal transduction
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057058
View Gene Order
ENSBTAG00000000641
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q86WV1
TrEMBL J3QRG3 J3QS38 V9HW03
UniProt Splice Variant
Entrez Gene 8631
UniGene Hs.316931
RefSeq NM_001075099 NM_003726 XM_005257756 XM_005257757
HUGO HGNC:15605
OMIM 604969
CCDS CCDS32674
HPRD 05396
IMGT
EMBL AC006468 AC027152 AC036222 AC090627 BC047870 CH471109 EU668346 Y11215
GenPept AAH47870 ACF94499 CAA72101 EAW94747 EAW94749 EAW94750
RNA Seq Atlas 8631

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca