Version 5.4
Homo sapiens Gene: CAPN1
Summary
InnateDB Gene IDBG-56732.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN1
Gene Name calpain 1, (mu/I) large subunit
Synonyms CANP; CANP1; CANPL1; muCANP; muCL
Species Homo sapiens
Ensembl Gene ENSG00000014216
Encoded Proteins
IDBP-56734
calpain 1, (mu/I) large subunit
IDBP-584042
calpain 1, (mu/I) large subunit
IDBP-596048
calpain 1, (mu/I) large subunit
IDBP-597007
calpain 1, (mu/I) large subunit
IDBP-603156
calpain 1, (mu/I) large subunit
IDBP-586740
calpain 1, (mu/I) large subunit
IDBP-598217
calpain 1, (mu/I) large subunit
IDBP-589559
calpain 1, (mu/I) large subunit
IDBP-601293
calpain 1, (mu/I) large subunit
IDBP-594083
calpain 1, (mu/I) large subunit
IDBP-595284
calpain 1, (mu/I) large subunit
IDBP-602918
calpain 1, (mu/I) large subunit
IDBP-590581
calpain 1, (mu/I) large subunit
IDBP-593663
calpain 1, (mu/I) large subunit
IDBP-599610
calpain 1, (mu/I) large subunit
IDBP-585332
calpain 1, (mu/I) large subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65180566-65212006
Strand Forward strand
Band q13.1
Transcripts
ENST00000279247 ENSP00000279247
ENST00000528396 ENSP00000435847
ENST00000529133 ENSP00000432512
ENST00000533820 ENSP00000435272
ENST00000527739 ENSP00000433823
ENST00000526966 ENSP00000431528
ENST00000533129 ENSP00000431686
ENST00000524773 ENSP00000434176
ENST00000530442
ENST00000528739
ENST00000532285 ENSP00000436693
ENST00000527189
ENST00000527469
ENST00000534373 ENSP00000431793
ENST00000526954 ENSP00000436002
ENST00000531068 ENSP00000435092
ENST00000527699 ENSP00000431172
ENST00000533909 ENSP00000435198
ENST00000527323 ENSP00000431984
ENST00000526468 ENSP00000433366
ENST00000527897
ENST00000533079
ENST00000527887
ENST00000530495
ENST00000525013
ENST00000528165
ENST00000533704
ENST00000530567
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 97 [view]
Protein-Protein 97 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0008284 positive regulation of cell proliferation
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0032801 receptor catabolic process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024942
View Gene Order
ENSBTAG00000010230
Not yet available
Pathways
NETPATH
NetPath_21
RANKL pathway
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
hsa04210
Apoptosis pathway
hsa05010
Alzheimer's disease pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
ptp1bpathway
Signaling events mediated by PTP1B
Cross-References
SwissProt P07384
TrEMBL A0A024R5A3 E9PIA9 E9PJA6 E9PJJ3 E9PLC9 E9PLX0 E9PMC6 E9PQB3 E9PSA6
UniProt Splice Variant
Entrez Gene 823
UniGene Hs.502842 Hs.735492
RefSeq NM_001198868 NM_001198869 NM_005186 XM_006718698
HUGO HGNC:1476
OMIM 114220
CCDS CCDS44644
HPRD 00253
IMGT
EMBL AP003068 AY550975 AY796340 BC008751 BC017200 BC075862 CH471076 X04366
GenPept AAH08751 AAH17200 AAH75862 AAT52221 AAV41878 CAA27881 EAW74367 EAW74370
RNA Seq Atlas 823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca