InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACPP

Summary

InnateDB Gene

IDBG-56768.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACPP

Gene Name

acid phosphatase, prostate

Synonyms

5\'-NT; ACP-3; ACP3

Species

Homo sapiens

Ensembl Gene

ENSG00000014257

Encoded Proteins

IDBP-56770

acid phosphatase, prostate

IDBP-56772

acid phosphatase, prostate

IDBP-476084

acid phosphatase, prostate

IDBP-476050

acid phosphatase, prostate

IDBP-475063

acid phosphatase, prostate

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:132317367-132368298

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000351273	ENSP00000323036
ENST00000336375	ENSP00000337471
ENST00000495911	ENSP00000418366
ENST00000475741	ENSP00000417744
ENST00000493235
ENST00000489084
ENST00000483689
ENST00000512463
ENST00000507647	ENSP00000422036

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003993	acid phosphatase activity
GO:0005515	protein binding
GO:0008253	5'-nucleotidase activity
GO:0016791	phosphatase activity
GO:0033265	choline binding
GO:0042131	thiamine phosphate phosphatase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0052642	lysophosphatidic acid phosphatase activity

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006772	thiamine metabolic process
GO:0009117	nucleotide metabolic process
GO:0016311	dephosphorylation
GO:0046085	adenosine metabolic process
GO:0051930	regulation of sensory perception of pain
GO:0060168	positive regulation of adenosine receptor signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005765	lysosomal membrane
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0012506	vesicle membrane
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0030175	filopodium
GO:0031985	Golgi cisterna
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032561

View Gene Order

ENSBTAG00000011634

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00740

Riboflavin metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

P15309

TrEMBL

E9PFE6 Q6LBH1

UniProt Splice Variant

Entrez Gene

UniGene

Hs.433060

RefSeq

NM_001099 NM_001134194

HUGO

HGNC:125

OMIM

171790

CCDS

CCDS3073 CCDS46916

HPRD

IMGT

EMBL

AB102888 AC020633 AK300540 BC007460 BC008493 BC016344 CH471052 M24902 M34840 M97580 M97581 M97582 M97583 M97584 M97585 M97586 M97587 M97588 M97589 U07083 U07085 U07086 U07088 U07091 U07092 U07093 U07095 U07097 X52174 X53605 X71391 X74961

GenPept

AAA60021 AAA60022 AAA69694 AAB60640 AAH07460 AAH08493 AAH16344 BAD89417 BAG62248 CAA36422 CAA37673 CAA50514 CAA52913 EAW79203 EAW79205

RNA Seq Atlas