Version 5.4
Homo sapiens Gene: WWC1
Summary
InnateDB Gene IDBG-56833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WWC1
Gene Name WW and C2 domain containing 1
Synonyms HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168
Species Homo sapiens
Ensembl Gene ENSG00000113645
Encoded Proteins
IDBP-56835
WW and C2 domain containing 1
IDBP-242683
WW and C2 domain containing 1
IDBP-481779
WW and C2 domain containing 1
IDBP-476176
WW and C2 domain containing 1
IDBP-477847
WW and C2 domain containing 1
IDBP-810236
WW and C2 domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:168291651-168472303
Strand Forward strand
Band q34
Transcripts
ENST00000265293 ENSP00000265293
ENST00000393895 ENSP00000377473
ENST00000521089 ENSP00000427772
ENST00000523043
ENST00000519859
ENST00000519659
ENST00000517425
ENST00000524228 ENSP00000429339
ENST00000517646
ENST00000518334
ENST00000524093
ENST00000524038 ENSP00000428084
ENST00000522140
ENST00000521391
ENST00000518204
ENST00000624315
ENST00000619752 ENSP00000483898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0030674 protein binding, bridging
GO:0032947 protein complex scaffold
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0016477 cell migration
GO:0030010 establishment of cell polarity
GO:0032386 regulation of intracellular transport
GO:0035329 hippo signaling
GO:0035330 regulation of hippo signaling
GO:0035331 negative regulation of hippo signaling
GO:0043410 positive regulation of MAPK cascade
GO:0046621 negative regulation of organ growth
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032587 ruffle membrane
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018849
View Gene Order
ENSBTAG00000013880
Not yet available
Pathways
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8IX03
TrEMBL H0YAU4
UniProt Splice Variant
Entrez Gene 23286
UniGene Hs.484047
RefSeq NM_001161661 NM_001161662 NM_015238 XM_005265850 XM_005265851 XM_005265852 XM_005265853 XM_006714835
HUGO HGNC:29435
OMIM 610533
CCDS CCDS4366 CCDS54945
HPRD
IMGT
EMBL AB020676 AC020894 AC026689 AF506799 AF530058 AK296323 AY189820 BC004394 BC017746 BX640827
GenPept AAH04394 AAH17746 AAO15881 AAO73817 AAQ09942 BAA74892 BAG59017 CAE45903
RNA Seq Atlas 23286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca