Version 5.4
Homo sapiens Gene: HOXB6
Summary
InnateDB Gene IDBG-56845.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXB6
Gene Name homeobox B6
Synonyms Hox-2.2; HOX2; HOX2B; HU-2
Species Homo sapiens
Ensembl Gene ENSG00000108511
Encoded Proteins
IDBP-56847
homeobox B6
IDBP-473893
homeobox B6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48595751-48604992
Strand Reverse strand
Band q21.32
Transcripts
ENST00000225648 ENSP00000225648
ENST00000484302 ENSP00000420009
ENST00000470193
ENST00000490419
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0034101 erythrocyte homeostasis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000000690
View Gene Order
Cross-References
SwissProt P17509
TrEMBL
UniProt Splice Variant
Entrez Gene 3216
UniGene Hs.652929 Hs.98428
RefSeq XM_005257284 NM_018952 XM_005257283
HUGO HGNC:5117
OMIM 142961
CCDS CCDS11531
HPRD 00849
IMGT
EMBL AF287967 AJ270993 AK292200 BC014651 CH471109 K02571 M30597 X58431
GenPept AAA36004 AAG31552 AAH14651 BAF84889 CAA41335 CAA41336 CAB65909 EAW94728 EAW94729 EAW94730 EAW94731
RNA Seq Atlas 3216

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca