Version 5.4
Homo sapiens Gene: TET3
Summary
InnateDB Gene IDBG-56864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TET3
Gene Name tet methylcytosine dioxygenase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187605
Encoded Proteins
IDBP-56868
tet methylcytosine dioxygenase 3
IDBP-295536
tet methylcytosine dioxygenase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:73986404-74108176
Strand Forward strand
Band p13.1
Transcripts
ENST00000305799 ENSP00000307803
ENST00000409262 ENSP00000386869
ENST00000475405
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0070579 methylcytosine dioxygenase activity
Biological Process
GO:0006493 protein O-linked glycosylation
GO:0044727 DNA demethylation of male pronucleus
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055114 oxidation-reduction process
GO:0080111 DNA demethylation
GO:0080182 histone H3-K4 trimethylation
Cellular Component
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034832
View Gene Order
ENSBTAG00000022381
Not yet available
Pathways
NETPATH
REACTOME
REACT_200682
TET1,2,3 and TDG demethylate DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O43151
TrEMBL J3KNF3 K9JJH7
UniProt Splice Variant
Entrez Gene 200424
UniGene Hs.516107
RefSeq NM_001287491 XM_005264187 XM_006711963
HUGO HGNC:28313
OMIM 613555
CCDS CCDS46339
HPRD
IMGT
EMBL AB007861 AC073263 AC110801 AF466365 BC022243 HQ220209
GenPept AAH22243 AAO33386 AAX93057 ADU77107 BAA23697
RNA Seq Atlas 200424

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca