Version 5.4
Homo sapiens Gene: BAG1
Summary
InnateDB Gene IDBG-56882.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAG1
Gene Name BCL2-associated athanogene
Synonyms BAG-1; HAP; RAP46
Species Homo sapiens
Ensembl Gene ENSG00000107262
Encoded Proteins
IDBP-56886
BCL2-associated athanogene
IDBP-56888
BCL2-associated athanogene
IDBP-474634
BCL2-associated athanogene
IDBP-479644
BCL2-associated athanogene
IDBP-477405
BCL2-associated athanogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:33247820-33264763
Strand Reverse strand
Band p13.3
Transcripts
ENST00000379707 ENSP00000369029
ENST00000379704 ENSP00000369026
ENST00000379701
ENST00000493917
ENST00000468274
ENST00000473464
ENST00000473781 ENSP00000419092
ENST00000467389
ENST00000488499 ENSP00000417576
ENST00000472232 ENSP00000420514
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 94 [view]
Protein-Protein 86 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0051087 chaperone binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006915 apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0030182 neuron differentiation
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070389 chaperone cofactor-dependent protein refolding
GO:0070585 protein localization to mitochondrion
GO:2000672 negative regulation of motor neuron apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028416
View Gene Order
ENSBTAG00000017845
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.377484
RefSeq NM_001172415 NM_004323
HUGO
OMIM
CCDS CCDS35004 CCDS55301
HPRD 03292
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca