InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: USP9X

Summary

InnateDB Gene

IDBG-57113.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP9X

Gene Name

ubiquitin specific peptidase 9, X-linked

Synonyms

DFFRX; FAF; FAM; MRX99

Species

Homo sapiens

Ensembl Gene

ENSG00000124486

Encoded Proteins

IDBP-57115

ubiquitin specific peptidase 9, X-linked

IDBP-57119

ubiquitin specific peptidase 9, X-linked

IDBP-475525

ubiquitin specific peptidase 9, X-linked

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:41085635-41236579

Strand

Forward strand

Band

p11.4

Transcripts

ENST00000378308	ENSP00000367558
ENST00000324545	ENSP00000316357
ENST00000467173
ENST00000465386
ENST00000463829
ENST00000462850	ENSP00000420570
ENST00000487625
ENST00000485180

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	128 [view]
Protein-Protein	128 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0036459	ubiquitinyl hydrolase activity
GO:0070410	co-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007292	female gamete generation
GO:0009791	post-embryonic development
GO:0010467	gene expression
GO:0016579	protein deubiquitination
GO:0021698	cerebellar cortex structural organization
GO:0021766	hippocampus development
GO:0030509	BMP signaling pathway
GO:0048675	axon extension
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:1990138	neuron projection extension