Homo sapiens Gene: PPP1CC | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-57303.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | PPP1CC | ||||||||||||||||||||||||||||
Gene Name | protein phosphatase 1, catalytic subunit, gamma isozyme | ||||||||||||||||||||||||||||
Synonyms | PP-1G; PP1C; PPP1G | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000186298 | ||||||||||||||||||||||||||||
Encoded Proteins |
protein phosphatase 1, catalytic subunit, gamma isozyme
protein phosphatase 1, catalytic subunit, gamma isozyme
protein phosphatase 1, catalytic subunit, gamma isozyme
protein phosphatase 1, catalytic subunit, gamma isozyme
protein phosphatase 1, catalytic subunit, gamma isozyme
protein phosphatase 1, catalytic subunit, gamma isozyme
protein phosphatase 1, catalytic subunit, gamma isozyme
protein phosphatase 1, catalytic subunit, gamma isozyme
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||
Summary |
PPP1CC dephosphorylates RNA sensors, RIG-I (DDX58) and MDA5 (IFIH1), to induce anti-viral IFNB production.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||
Summary |
[Mus musculus] PPP1CC dephosphorylates RNA sensors, RIG-I (DDX58) and MDA5 (IFIH1), to induce anti-viral IFNB production.
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Entrez Gene | |||||||||||||||||||||||||||||
Summary |
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 12:110719680-110742939 | ||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||
Band | q24.11 | ||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH |
TGF_beta_Receptor pathway
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REACTOME |
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
Separation of Sister Chromatids pathway
Downregulation of TGF-beta receptor signaling pathway
TGF-beta receptor signaling activates SMADs pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Metabolism of lipids and lipoproteins pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
M Phase pathway
Mitotic Anaphase pathway
TGFBR1 KD Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Metabolism pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Lipid digestion, mobilization, and transport pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Mitotic Metaphase and Anaphase pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Long-term potentiation pathway
Insulin signaling pathway pathway
Focal adhesion pathway
Vascular smooth muscle contraction pathway
Oocyte meiosis pathway
mRNA surveillance pathway pathway
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INOH |
GPCR Dopamine D1like receptor signaling pathway pathway
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PID NCI |
Aurora B signaling
Insulin-mediated glucose transport
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Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
UniGene | Hs.619441 Hs.731379 Hs.79081 | ||||||||||||||||||||||||||||
RefSeq | NM_001244974 NM_002710 | ||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS58279 CCDS9150 | ||||||||||||||||||||||||||||
HPRD | 08911 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||