InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APOL1

Summary

InnateDB Gene

IDBG-5737.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOL1

Gene Name

apolipoprotein L, 1

Synonyms

APO-L; APOL; APOL-I; FSGS4

Species

Homo sapiens

Ensembl Gene

ENSG00000100342

Encoded Proteins

IDBP-5739

apolipoprotein L, 1

IDBP-235712

apolipoprotein L, 1

IDBP-235714

apolipoprotein L, 1

IDBP-374571

apolipoprotein L, 1

IDBP-374572

apolipoprotein L, 1

IDBP-374578

apolipoprotein L, 1

IDBP-374581

apolipoprotein L, 1

IDBP-374583

apolipoprotein L, 1

IDBP-374586

apolipoprotein L, 1

IDBP-374598

apolipoprotein L, 1

IDBP-374602

apolipoprotein L, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:36253010-36267530

Strand

Forward strand

Band

q12.3

Transcripts

ENST00000319136	ENSP00000317674
ENST00000397279	ENSP00000380449
ENST00000397278	ENSP00000380448
ENST00000422706	ENSP00000411507
ENST00000426053	ENSP00000388477
ENST00000422471	ENSP00000391206
ENST00000427990	ENSP00000391302
ENST00000439680	ENSP00000397141
ENST00000438034	ENSP00000404525
ENST00000433768	ENSP00000392514
ENST00000431184	ENSP00000392857
ENST00000475519

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0008289	lipid binding

Biological Process

GO:0006821	chloride transport
GO:0006869	lipid transport
GO:0008203	cholesterol metabolic process
GO:0019835	cytolysis
GO:0031640	killing of cells of other organism
GO:0042157	lipoprotein metabolic process
GO:0045087	innate immune response
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031224	intrinsic component of membrane
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0072562	blood microparticle

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_160163

Scavenging of heme from plasma pathway

REACT_160300

Binding and Uptake of Ligands by Scavenger Receptors pathway

KEGG

hsa05143

African trypanosomiasis pathway

INOH

PID NCI

Cross-References

SwissProt

O14791

TrEMBL

B1AH96 G8JL88 U5LGU2

UniProt Splice Variant

Entrez Gene

8542

UniGene

Hs.114309 Hs.607747

RefSeq

NM_003661 NM_001136540 NM_001136541 NM_145343 XM_005261796

HUGO

HGNC:618

OMIM

603743

CCDS

CCDS13926 CCDS13925 CCDS46702

HPRD

04774

IMGT

EMBL

AF019225 AF305224 AF305428 AF323540 AF323543 AF323544 AF323545 AF323546 AF323547 AF323548 AK300454 BC143039 KC339295 Z82215

GenPept

AAB81218 AAG53690 AAI43040 AAK11591 AAK20210 AAL09358 AGX24961 BAG62174 CAI22438 CAQ09089

RNA Seq Atlas

8542