Version 5.4
| Homo sapiens Gene: GNGT2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-57490.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | GNGT2 | ||||||||||||||||||
| Gene Name | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 | ||||||||||||||||||
| Synonyms | G-GAMMA-8; G-GAMMA-C; GNG8; GNG9; GNGT8 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000167083 | ||||||||||||||||||
| Encoded Proteins |
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 17:49202791-49210574 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q21.32 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Prostacyclin signalling through prostacyclin receptor pathway
Platelet homeostasis pathway
ADP signalling through P2Y purinoceptor 12 pathway
ADP signalling through P2Y purinoceptor 1 pathway
Thromboxane signalling through TP receptor pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (i) signalling events pathway
G beta:gamma signalling through PI3Kgamma pathway
G beta:gamma signalling through PLC beta pathway
G alpha (12/13) signalling events pathway
G alpha (s) signalling events pathway
G alpha (z) signalling events pathway
Glucagon-type ligand receptors pathway
Class B/2 (Secretin family receptors) pathway
G-protein activation pathway
Opioid Signalling pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
GABA B receptor activation pathway
Presynaptic function of Kainate receptors pathway
Activation of G protein gated Potassium channels pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
GABA receptor activation pathway
G protein gated Potassium channels pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Inwardly rectifying K+ channels pathway
Activation of Kainate Receptors upon glutamate binding pathway
Potassium Channels pathway
Transmission across Chemical Synapses pathway
GPCR ligand binding pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Signal amplification pathway
Aquaporin-mediated transport pathway
Hemostasis pathway
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| KEGG |
Chemokine signaling pathway pathway
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| INOH |
GPCR Adenosine A2A receptor signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
Visual signal transduction: Cones
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| Cross-References | |||||||||||||||||||
| SwissProt | O14610 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 2793 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001198754 NM_001198755 NM_001198756 NM_031498 XM_006721819 | ||||||||||||||||||
| HUGO | HGNC:4412 | ||||||||||||||||||
| OMIM | 139391 | ||||||||||||||||||
| CCDS | CCDS11545 | ||||||||||||||||||
| HPRD | 06792 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF001159 AF001160 AF365870 AF493876 AK312839 BC008663 CH471109 | ||||||||||||||||||
| GenPept | AAB70039 AAH08663 AAK53384 AAM12590 BAG35693 EAW94688 EAW94689 | ||||||||||||||||||
| RNA Seq Atlas | 2793 | ||||||||||||||||||