Version 5.4
Homo sapiens Gene: TUBB2B
Summary
InnateDB Gene IDBG-57587.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUBB2B
Gene Name tubulin, beta 2B class IIb
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137285
Encoded Proteins
IDBP-57589
tubulin, beta 2B class IIb
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:3224261-3231730
Strand Reverse strand
Band p25.2
Transcripts
ENST00000259818 ENSP00000259818
ENST00000473006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0001764 neuron migration
GO:0006184 GTP catabolic process
GO:0006457 protein folding
GO:0007017 microtubule-based process
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
GO:0051258 protein polymerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000045136
View Gene Order
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_15510
Recruitment of NuMA to mitotic centrosomes pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_16967
Post-chaperonin tubulin folding pathway pathway
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16956
Formation of tubulin folding intermediates by CCT/TriC pathway
REACT_11039
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
REACT_11050
Transport of connexons to the plasma membrane pathway
REACT_9509
Gap junction assembly pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_16952
Protein folding pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111045
Developmental Biology pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_9411
Gap junction trafficking pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_115566
Cell Cycle pathway
REACT_267716
Orphan transporters pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_604
Hemostasis pathway
REACT_11123
Membrane Trafficking pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04540
Gap junction pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9BVA1
TrEMBL A0A024QZU2 A1L195 O43209
UniProt Splice Variant
Entrez Gene 347733
UniGene Hs.300701 Hs.725581
RefSeq NM_178012
HUGO HGNC:30829
OMIM 612850
CCDS CCDS4485
HPRD
IMGT
EMBL AF035316 AK289433 AL445309 BC001352 BC063610 BC127872 BT019930 CH471087 CR456788
GenPept AAB88188 AAH01352 AAH63610 AAI27873 AAV38733 BAF82122 CAG33069 CAI40952 EAW55125 EAW55126 EAW55127
RNA Seq Atlas 347733

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca