Homo sapiens Gene: FBXW11

Summary
InnateDB Gene IDBG-57611.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol FBXW11
Gene Name F-box and WD repeat domain containing 11
Synonyms BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos
Species Homo sapiens
Ensembl Gene ENSG00000072803
Encoded Proteins
IDBP-57613 F-box and WD repeat domain containing 11
IDBP-57615 F-box and WD repeat domain containing 11
IDBP-242872 F-box and WD repeat domain containing 11
IDBP-597259 F-box and WD repeat domain containing 11
IDBP-476030 F-box and WD repeat domain containing 11
IDBP-479399 F-box and WD repeat domain containing 11
IDBP-474885 F-box and WD repeat domain containing 11
IDBP-474509 F-box and WD repeat domain containing 11
IDBP-474874 F-box and WD repeat domain containing 11
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5: 171288553-171433877
Strand Reverse strand
Band q35.1
Transcripts
ENST00000265094  ENSP00000265094
ENST00000296933  ENSP00000296933
ENST00000393802  ENSP00000377391
ENST00000425623  ENSP00000444929
ENST00000523843  ENSP00000430104
ENST00000518106 
ENST00000522376 
ENST00000522891 
ENST00000519693  ENSP00000427777
ENST00000517395  ENSP00000428753
ENST00000520376  ENSP00000431100
ENST00000518752  ENSP00000429818
ENST00000522507 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 93 [view]
Protein‑Protein  93
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0004842 ubiquitin-protein ligase activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006470 protein dephosphorylation
GO:0007049 cell cycle
GO:0016055 Wnt receptor signaling pathway
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648 protein destabilization
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0042753 positive regulation of circadian rhythm
GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-dependent
GO:0045893 positive regulation of transcription, DNA-dependent
GO:0048511 rhythmic process
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000020271 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000015376 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
NetPath_56 Prolactin pathway
NetPath_9 TNFalpha pathway
REACTOME
KEGG
hsa04710  Circadian rhythm - mammal
hsa04340  Hedgehog signaling pathway
hsa04114  Oocyte meiosis
hsa05131  Shigellosis
hsa04120  Ubiquitin mediated proteolysis
hsa04310  Wnt signaling pathway
INOH
PID BIOCARTA
PID NCI
hedgehog_glipathway Hedgehog signaling events mediated by Gli proteins
ps1pathway Presenilin action in Notch and Wnt signaling
vegfr1_2_pathway Signaling events mediated by VEGFR1 and VEGFR2
Cross-References
SwissProt Q9UKB1 
TrEMBL B4DH70 E5RG78 E5RGC1 E5RH92
UniProt Splice Variant
Entrez Gene 23291 
UniGene Hs.484138 Hs.596652 Hs.599706 Hs.617737
RefSeq NM_012300  NM_033644  NM_033645 
HUGO 13607 
OMIM 605651
CCDS CCDS34289  CCDS47340  CCDS47341 
HPRD 07294
IMGT
EMBL AB014596 AB033279 AB033280 AB033281 AC011387 AC011410 AC113342 AF176022 AK294956 AK314999 BC026213
GenPept AAF04528  AAH26213  BAA31671  BAA92329  BAA92330  BAA92331  BAG37495  BAG58031 
ImmGen FBXW11 (murine) 
RNA Seq Atlas 23291