Homo sapiens Gene: FBXW11
Summary
InnateDB Gene IDBG-57611.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol FBXW11
Gene Name F-box and WD repeat domain containing 11
Synonyms BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;
Species Homo sapiens
Ensembl Gene ENSG00000072803
Encoded Proteins
F-box and WD repeat domain containing 11
F-box and WD repeat domain containing 11
F-box and WD repeat domain containing 11
F-box and WD repeat domain containing 11
F-box and WD repeat domain containing 11
F-box and WD repeat domain containing 11
F-box and WD repeat domain containing 11
F-box and WD repeat domain containing 11
F-box and WD repeat domain containing 11
Protein Structure
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:171288553-171433877
Strand Reverse strand
Band q35.1
Transcripts
ENST00000265094 ENSP00000265094
ENST00000296933 ENSP00000296933
ENST00000393802 ENSP00000377391
ENST00000425623 ENSP00000444929
ENST00000523843 ENSP00000430104
ENST00000518106
ENST00000522376
ENST00000522891
ENST00000519693 ENSP00000427777
ENST00000517395 ENSP00000428753
ENST00000520376 ENSP00000431100
ENST00000518752 ENSP00000429818
ENST00000522507
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 93 [view]
Protein-Protein 93 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein ligase activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006470 protein dephosphorylation
GO:0007049 cell cycle
GO:0016055 Wnt receptor signaling pathway
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648 protein destabilization
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0042753 positive regulation of circadian rhythm
GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-dependent
GO:0045893 positive regulation of transcription, DNA-dependent
GO:0048511 rhythmic process
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
Prolactin pathway
REACTOME
KEGG
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Ubiquitin mediated proteolysis pathway
Circadian rhythm - mammal pathway
Oocyte meiosis pathway
Shigellosis pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by VEGFR1 and VEGFR2
Hedgehog signaling events mediated by Gli proteins
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt Q9UKB1
TrEMBL B4DH70 E5RG78 E5RGC1 E5RH92
UniProt Splice Variant
Entrez Gene 23291
UniGene Hs.484138 Hs.596652 Hs.599706 Hs.617737
RefSeq NM_012300 NM_033644 NM_033645
HUGO 13607
OMIM 605651
CCDS CCDS34289 CCDS47340 CCDS47341
HPRD 07294
IMGT
EMBL AB014596 AB033279 AB033280 AB033281 AC011387 AC011410 AC113342 AF176022 AK294956 AK314999 BC026213
GenPept AAF04528 AAH26213 BAA31671 BAA92329 BAA92330 BAA92331 BAG37495 BAG58031
ImmGen FBXW11 (murine)
RNA Seq Atlas 23291