Version 5.4
Homo sapiens Gene: HTRA2
Summary
InnateDB Gene IDBG-57753.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTRA2
Gene Name HtrA serine peptidase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115317
Encoded Proteins
IDBP-57755
HtrA serine peptidase 2
IDBP-57759
HtrA serine peptidase 2
IDBP-380915
HtrA serine peptidase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74529377-74533348
Strand Forward strand
Band p13.1
Transcripts
ENST00000258080 ENSP00000258080
ENST00000352222 ENSP00000312893
ENST00000437202 ENSP00000399166
ENST00000462909
ENST00000467961
ENST00000484881
ENST00000484352
ENST00000465521
ENST00000482205
ENST00000482331
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 64 [view]
Protein-Protein 63 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0051082 unfolded protein binding
Biological Process
GO:0006508 proteolysis
GO:0006672 ceramide metabolic process
GO:0007005 mitochondrion organization
GO:0007628 adult walking behavior
GO:0008344 adult locomotory behavior
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009635 response to herbicide
GO:0010942 positive regulation of cell death
GO:0016540 protein autoprocessing
GO:0019742 pentacyclic triterpenoid metabolic process
GO:0030900 forebrain development
GO:0034605 cellular response to heat
GO:0040014 regulation of multicellular organism growth
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045786 negative regulation of cell cycle
GO:0048666 neuron development
GO:0060548 negative regulation of cell death
GO:0071363 cellular response to growth factor stimulus
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0035631 CD40 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068329
View Gene Order
ENSBTAG00000020124
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05012
Parkinson's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.731388
RefSeq NM_013247 NM_145074
HUGO
OMIM
CCDS CCDS1951 CCDS1952
HPRD 05919
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca