Version 5.4
Homo sapiens Gene: MUS81
Summary
InnateDB Gene IDBG-57860.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUS81
Gene Name MUS81 endonuclease homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172732
Encoded Proteins
IDBP-57862
MUS81 endonuclease homolog (S. cerevisiae)
IDBP-584159
MUS81 endonuclease homolog (S. cerevisiae)
IDBP-586460
MUS81 endonuclease homolog (S. cerevisiae)
IDBP-583135
MUS81 endonuclease homolog (S. cerevisiae)
IDBP-596835
MUS81 endonuclease homolog (S. cerevisiae)
IDBP-598894
MUS81 endonuclease homolog (S. cerevisiae)
IDBP-594237
MUS81 endonuclease homolog (S. cerevisiae)
IDBP-584652
MUS81 endonuclease homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65857126-65867653
Strand Forward strand
Band q13.1
Transcripts
ENST00000308110 ENSP00000307853
ENST00000529857 ENSP00000431979
ENST00000533035 ENSP00000432287
ENST00000525768 ENSP00000431478
ENST00000524647 ENSP00000433473
ENST00000529374 ENSP00000434305
ENST00000533555
ENST00000531905
ENST00000530111 ENSP00000433809
ENST00000530928
ENST00000525147
ENST00000525224
ENST00000529786
ENST00000530282
ENST00000533519
ENST00000529742 ENSP00000435277
ENST00000525006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0048257 3'-flap endonuclease activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0008152 metabolic process
GO:0072429 response to intra-S DNA damage checkpoint signaling
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0045171 intercellular bridge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024906
View Gene Order
ENSBTAG00000021456
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03440
Homologous recombination pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.288798
RefSeq NM_025128 XM_005274307
HUGO
OMIM
CCDS CCDS8115
HPRD 09419
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca