Version 5.4
Homo sapiens Gene: SIX5
Summary
InnateDB Gene IDBG-57970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIX5
Gene Name SIX homeobox 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177045
Encoded Proteins
IDBP-57972
SIX homeobox 5
IDBP-593790
SIX homeobox 5
IDBP-585085
SIX homeobox 5
IDBP-812271
SIX homeobox 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45764785-45769226
Strand Reverse strand
Band q13.32
Transcripts
ENST00000317578 ENSP00000316842
ENST00000560160 ENSP00000453239
ENST00000560168 ENSP00000453189
ENST00000622857 ENSP00000481365
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002088 lens development in camera-type eye
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007286 spermatid development
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040841
View Gene Order
ENSBTAG00000013346
Not yet available
Cross-References
SwissProt Q8N196
TrEMBL H0YLF6
UniProt Splice Variant
Entrez Gene 147912
UniGene Hs.43314
RefSeq NM_175875
HUGO HGNC:10891
OMIM 600963
CCDS CCDS12673
HPRD
IMGT
EMBL AC074212 AK074826 BC033204 BU859227 X84813
GenPept AAH33204
RNA Seq Atlas 147912

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca