Version 5.4
Homo sapiens Gene: BNIP1
Summary
InnateDB Gene IDBG-57973.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BNIP1
Gene Name BCL2/adenovirus E1B 19kDa interacting protein 1
Synonyms NIP1; SEC20; TRG-8
Species Homo sapiens
Ensembl Gene ENSG00000113734
Encoded Proteins
IDBP-57975
BCL2/adenovirus E1B 19kDa interacting protein 1
IDBP-57977
BCL2/adenovirus E1B 19kDa interacting protein 1
IDBP-57979
BCL2/adenovirus E1B 19kDa interacting protein 1
IDBP-242948
BCL2/adenovirus E1B 19kDa interacting protein 1
IDBP-484129
BCL2/adenovirus E1B 19kDa interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:173144442-173164387
Strand Forward strand
Band q35.1
Transcripts
ENST00000351486 ENSP00000239215
ENST00000231668 ENSP00000231668
ENST00000352523 ENSP00000239214
ENST00000393770 ENSP00000377365
ENST00000519459 ENSP00000429717
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
Biological Process
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0007029 endoplasmic reticulum organization
GO:0016192 vesicle-mediated transport
GO:0016320 endoplasmic reticulum membrane fusion
GO:0043066 negative regulation of apoptotic process
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031201 SNARE complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024191
View Gene Order
ENSBTAG00000002021
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.145726
RefSeq NM_001205 NM_013978 NM_013979 NM_013980
HUGO
OMIM
CCDS CCDS43400 CCDS4384 CCDS4385 CCDS4386
HPRD 04480
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca