InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NCK1

Summary

InnateDB Gene

IDBG-58017.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCK1

Gene Name

NCK adaptor protein 1

Synonyms

NCK; nck-1; NCKalpha

Species

Homo sapiens

Ensembl Gene

ENSG00000158092

Encoded Proteins

IDBP-58019

NCK adaptor protein 1

IDBP-477840

NCK adaptor protein 1

IDBP-476302

NCK adaptor protein 1

IDBP-482173

NCK adaptor protein 1

IDBP-478717

NCK adaptor protein 1

IDBP-475723

NCK adaptor protein 1

IDBP-474024

NCK adaptor protein 1

IDBP-473834

NCK adaptor protein 1

IDBP-482740

NCK adaptor protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:136862208-136949823

Strand

Forward strand

Band

q22.3

Transcripts

ENST00000288986	ENSP00000288986
ENST00000481752	ENSP00000417273
ENST00000491539	ENSP00000419302
ENST00000485096	ENSP00000419677
ENST00000476286	ENSP00000418513
ENST00000460960
ENST00000478862
ENST00000488930	ENSP00000417729
ENST00000496489	ENSP00000419544
ENST00000469404	ENSP00000419631
ENST00000467911	ENSP00000418060
ENST00000482071

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 142 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	142 [view]
Protein-Protein	141 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0019887	protein kinase regulator activity
GO:0019904	protein domain specific binding
GO:0030159	receptor signaling complex scaffold activity
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0006417	regulation of translation
GO:0006469	negative regulation of protein kinase activity
GO:0007015	actin filament organization
GO:0007172	signal complex assembly
GO:0007411	axon guidance
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0030838	positive regulation of actin filament polymerization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0045087	innate immune response
GO:0045859	regulation of protein kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050852	T cell receptor signaling pathway
GO:0051707	response to other organism
GO:0060548	negative regulation of cell death

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0012506	vesicle membrane