InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HK2

Summary

InnateDB Gene

IDBG-58047.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HK2

Gene Name

hexokinase 2

Synonyms

HKII; HXK2

Species

Homo sapiens

Ensembl Gene

ENSG00000159399

Encoded Proteins

IDBP-58049

hexokinase 2

IDBP-295466

hexokinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:74833981-74893359

Strand

Forward strand

Band

p12

Transcripts

ENST00000290573	ENSP00000290573
ENST00000409174	ENSP00000387140
ENST00000472302

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005524	ATP binding
GO:0005536	glucose binding
GO:0008865	fructokinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019158	mannokinase activity

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0002931	response to ischemia
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0007595	lactation
GO:0008637	apoptotic mitochondrial changes
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0044281	small molecule metabolic process
GO:0046324	regulation of glucose import
GO:0046835	carbohydrate phosphorylation
GO:0051156	glucose 6-phosphate metabolic process
GO:0055085	transmembrane transport