Version 5.4
Homo sapiens Gene: NOL6
Summary
InnateDB Gene IDBG-58053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOL6
Gene Name nucleolar protein family 6 (RNA-associated)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165271
Encoded Proteins
IDBP-58055
nucleolar protein family 6 (RNA-associated)
IDBP-58057
nucleolar protein family 6 (RNA-associated)
IDBP-58059
nucleolar protein family 6 (RNA-associated)
IDBP-58061
nucleolar protein family 6 (RNA-associated)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:33461441-33473930
Strand Reverse strand
Band p13.3
Transcripts
ENST00000297990 ENSP00000297990
ENST00000353159 ENSP00000313978
ENST00000379471 ENSP00000368784
ENST00000379470 ENSP00000368783
ENST00000464829
ENST00000496319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006364 rRNA processing
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028430
View Gene Order
ENSBTAG00000003323
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.493709 Hs.634250
RefSeq NM_022917 NM_139235
HUGO
OMIM
CCDS CCDS6543 CCDS6544
HPRD 14832
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca