Version 5.4
Homo sapiens Gene: BANF1
Summary
InnateDB Gene IDBG-58220.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BANF1
Gene Name barrier to autointegration factor 1
Synonyms BAF; BCRP1; D14S1460; NGPS
Species Homo sapiens
Ensembl Gene ENSG00000175334
Encoded Proteins
IDBP-58222
barrier to autointegration factor 1
IDBP-378809
barrier to autointegration factor 1
IDBP-584618
barrier to autointegration factor 1
IDBP-602992
barrier to autointegration factor 1
IDBP-604054
barrier to autointegration factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66002079-66004149
Strand Forward strand
Band q13.1
Transcripts
ENST00000312175 ENSP00000310275
ENST00000445560 ENSP00000416128
ENST00000530204 ENSP00000431785
ENST00000524663
ENST00000524628
ENST00000533166 ENSP00000433760
ENST00000527348 ENSP00000432867
ENST00000528648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
Experimentally validated
Total 64 [view]
Protein-Protein 64 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007077 mitotic nuclear envelope disassembly
GO:0007084 mitotic nuclear envelope reassembly
GO:0009615 response to virus
GO:0015074 DNA integration
GO:0016032 viral process
GO:0075713 establishment of integrated proviral latency
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024844
View Gene Order
ENSBTAG00000031875
Not yet available
Pathways
NETPATH
REACTOME
REACT_160251
Clearance of Nuclear Envelope Membranes from Chromatin pathway
REACT_160242
Initiation of Nuclear Envelope Reformation pathway
REACT_9406
APOBEC3G mediated resistance to HIV-1 infection pathway
REACT_7991
Vpr-mediated nuclear import of PICs pathway
REACT_9058
2-LTR circle formation pathway
REACT_6866
Autointegration results in viral DNA circles pathway
REACT_6918
Integration of provirus pathway
REACT_6266
Early Phase of HIV Life Cycle pathway
REACT_6757
Interactions of Vpr with host cellular proteins pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_6256
HIV Life Cycle pathway
REACT_1275
Mitotic Anaphase pathway
REACT_765
Mitotic Prophase pathway
REACT_160113
Nuclear Envelope Reassembly pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_6185
HIV Infection pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_8990
Integration of viral DNA into host genomic DNA pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_116125
Disease pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PJJ8
UniProt Splice Variant
Entrez Gene 8815
UniGene
RefSeq NM_001143985 NM_003860
HUGO HGNC:17397
OMIM 603811
CCDS CCDS8125
HPRD 04817
IMGT
EMBL AP006287
GenPept
RNA Seq Atlas 8815

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca