Version 5.4
Homo sapiens Gene: REG3G
Summary
InnateDB Gene IDBG-58387.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REG3G
Gene Name regenerating islet-derived 3 gamma
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143954
Encoded Proteins
IDBP-58389
regenerating islet-derived 3 gamma
IDBP-242704
regenerating islet-derived 3 gamma
IDBP-295439
regenerating islet-derived 3 gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antibacterial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:79025686-79028505
Strand Forward strand
Band p12
Transcripts
ENST00000272324 ENSP00000272324
ENST00000393897 ENSP00000377475
ENST00000409471 ENSP00000387105
ENST00000498312
ENST00000490944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006953 acute-phase response
GO:0010838 positive regulation of keratinocyte proliferation
GO:0045617 negative regulation of keratinocyte differentiation
GO:0050830 defense response to Gram-positive bacterium
GO:0090303 positive regulation of wound healing
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q6UW15
TrEMBL
UniProt Splice Variant
Entrez Gene 130120
UniGene Hs.447084 Hs.742463
RefSeq NM_198448 NM_001008387 NM_001270040 XM_005264135
HUGO HGNC:29595
OMIM 609933
CCDS CCDS1962 CCDS58714
HPRD 10137
IMGT
EMBL AB161037 AB161038 AB161039 AC017004 AK292595 AY359047 AY428734 BC103852 BC103853 BC103854 CH471053 CR541938
GenPept AAI03853 AAI03854 AAI03855 AAQ89406 AAR88147 AAX88840 BAD51394 BAD51395 BAD51396 BAF85284 CAG46736 EAW99580 EAW99581
RNA Seq Atlas 130120

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca