Version 5.4
Homo sapiens Gene: PACS1
Summary
InnateDB Gene IDBG-58434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PACS1
Gene Name phosphofurin acidic cluster sorting protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000175115
Encoded Proteins
IDBP-58436
phosphofurin acidic cluster sorting protein 1
IDBP-599306
phosphofurin acidic cluster sorting protein 1
IDBP-599339
phosphofurin acidic cluster sorting protein 1
IDBP-585156
phosphofurin acidic cluster sorting protein 1
IDBP-587198
phosphofurin acidic cluster sorting protein 1
IDBP-593658
phosphofurin acidic cluster sorting protein 1
IDBP-601228
phosphofurin acidic cluster sorting protein 1
IDBP-596246
phosphofurin acidic cluster sorting protein 1
IDBP-601231
phosphofurin acidic cluster sorting protein 1
IDBP-584877
phosphofurin acidic cluster sorting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66070363-66244747
Strand Forward strand
Band q13.1
Transcripts
ENST00000320580 ENSP00000316454
ENST00000527224
ENST00000533756 ENSP00000437150
ENST00000527380 ENSP00000432639
ENST00000531298 ENSP00000437274
ENST00000524784 ENSP00000435037
ENST00000533811
ENST00000534273
ENST00000529757 ENSP00000432858
ENST00000528935 ENSP00000437052
ENST00000529795
ENST00000525798
ENST00000524815 ENSP00000433991
ENST00000531597 ENSP00000434012
ENST00000529677 ENSP00000432365
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044325 ion channel binding
Biological Process
GO:0000042 protein targeting to Golgi
GO:0016032 viral process
GO:0050690 regulation of defense response to virus by virus
GO:0072661 protein targeting to plasma membrane
Cellular Component
GO:0005829 cytosol
GO:0030137 COPI-coated vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024855
View Gene Order
ENSBTAG00000009026
Not yet available
Pathways
NETPATH
REACTOME
REACT_11103
Nef mediated downregulation of MHC class I complex cell surface expression pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6VY07
TrEMBL A0A024R5H6 B4DF77 E9PNG7 E9PNZ9 E9PPK2 E9PSE1 E9PSG7 H0YE62 Q9NTH2
UniProt Splice Variant
Entrez Gene 55690
UniGene Hs.644326
RefSeq NM_018026
HUGO HGNC:30032
OMIM 607492
CCDS CCDS8129
HPRD
IMGT
EMBL AB033001 AK001071 AK056361 AK096644 AK293966 AL137271 AP000759 AP000822 AP006287 AY320283 BC003173 BC009936 BC010096 BC052577 BC055288 CH471076
GenPept AAH03173 AAH09936 AAH10096 AAH52577 AAH55288 AAQ67682 BAA86489 BAA91491 BAB71164 BAC04831 BAG57338 CAB70669 EAW74502 EAW74504
RNA Seq Atlas 55690

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca