InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RASAL1

Summary

InnateDB Gene

IDBG-58455.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASAL1

Gene Name

RAS protein activator like 1 (GAP1 like)

Synonyms

RASAL

Species

Homo sapiens

Ensembl Gene

ENSG00000111344

Encoded Proteins

IDBP-58457

RAS protein activator like 1 (GAP1 like)

IDBP-383654

RAS protein activator like 1 (GAP1 like)

IDBP-590478

RAS protein activator like 1 (GAP1 like)

IDBP-588536

RAS protein activator like 1 (GAP1 like)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:113098819-113136239

Strand

Reverse strand

Band

q24.13

Transcripts

ENST00000261729	ENSP00000261729
ENST00000446861	ENSP00000395920
ENST00000418411
ENST00000546530	ENSP00000450244
ENST00000549444
ENST00000548055	ENSP00000448510
ENST00000551051
ENST00000546727
ENST00000548972
ENST00000547810

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029602

View Gene Order

ENSBTAG00000016739

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

ras_pathway

Regulation of Ras family activation

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.528693

RefSeq

NM_001193520 NM_001193521 NM_001301202 NM_004658 XM_005253950 XM_005253951 XM_006719641 XM_006719642

HUGO

OMIM

CCDS

CCDS55888 CCDS55889 CCDS73529 CCDS9165

HPRD

04986

IMGT

EMBL

GenPept

RNA Seq Atlas