Version 5.4
Homo sapiens Gene: HIF3A
Summary
InnateDB Gene IDBG-58490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIF3A
Gene Name hypoxia inducible factor 3, alpha subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124440
Encoded Proteins
IDBP-58494
hypoxia inducible factor 3, alpha subunit
IDBP-58496
hypoxia inducible factor 3, alpha subunit
IDBP-58502
hypoxia inducible factor 3, alpha subunit
IDBP-597884
hypoxia inducible factor 3, alpha subunit
IDBP-586520
hypoxia inducible factor 3, alpha subunit
IDBP-600766
hypoxia inducible factor 3, alpha subunit
IDBP-585316
hypoxia inducible factor 3, alpha subunit
IDBP-585445
hypoxia inducible factor 3, alpha subunit
IDBP-602078
hypoxia inducible factor 3, alpha subunit
IDBP-763888
IDBP-761471
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46297046-46343433
Strand Forward strand
Band q13.32
Transcripts
ENST00000244302
ENST00000244303 ENSP00000244303
ENST00000377670 ENSP00000366898
ENST00000291300
ENST00000300862 ENSP00000300862
ENST00000475432
ENST00000472815 ENSP00000434653
ENST00000533789 ENSP00000432809
ENST00000524533
ENST00000528563 ENSP00000435532
ENST00000533145 ENSP00000435200
ENST00000526506 ENSP00000432613
ENST00000525854
ENST00000529205
ENST00000531043 ENSP00000434700
ENST00000529542
ENST00000600383 ENSP00000471560
ENST00000600236
ENST00000600879 ENSP00000469031
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004328
View Gene Order
ENSBTAG00000018948
Not yet available
Pathways
NETPATH
REACTOME
REACT_120916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_121092
Regulation of gene expression by Hypoxia-inducible Factor pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_121311
Cellular response to hypoxia pathway
KEGG
INOH
PID NCI
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt Q9Y2N7
TrEMBL E9PB04 O95262 Q9UPH7
UniProt Splice Variant
Entrez Gene 64344
UniGene Hs.420830 Hs.646235
RefSeq NM_152795 XM_005259152 XM_006723324 NM_022462 NM_152794 NM_152796 XM_005259153 XM_005259154 XM_005259156 XM_006723325
HUGO HGNC:15825
OMIM 609976
CCDS CCDS12681 CCDS12682 CCDS42580
HPRD 17104
IMGT
EMBL AB054067 AB118749 AB295039 AC007193 AF079154 AF463492 AK021653 AK024095 AK027725 AK297828 BC080551 CH471126
GenPept AAC99397 AAD22667 AAD22668 AAH80551 AAL69947 BAB13865 BAB14824 BAB55324 BAB69689 BAD93355 BAG07185 BAG60164 EAW57410
RNA Seq Atlas 64344

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca