Homo sapiens Gene: UBE2R2
Summary
InnateDB Gene IDBG-58571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2R2
Gene Name ubiquitin-conjugating enzyme E2R 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000107341
Encoded Proteins
ubiquitin-conjugating enzyme E2R 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:33817567-33920404
Strand Forward strand
Band p13.3
Transcripts
ENST00000263228 ENSP00000263228
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0006513 protein monoubiquitination
GO:0070936 protein K48-linked ubiquitination
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt Q712K3
TrEMBL
UniProt Splice Variant
Entrez Gene 54926
UniGene Hs.740452
RefSeq NM_017811
HUGO HGNC:19907
OMIM 612506
CCDS CCDS6546
HPRD
IMGT
EMBL AJ240087 AK000426 AL139113 BC004862 BC047584 CH471071 CR457233
GenPept AAH04862 AAH47584 BAA91156 CAC80336 CAG33514 CAI39656 EAW58479 EAW58480
RNA Seq Atlas 54926