Version 5.4
Homo sapiens Gene: SUCLG1
Summary
InnateDB Gene IDBG-58676.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUCLG1
Gene Name succinate-CoA ligase, alpha subunit
Synonyms GALPHA; MTDPS9; SUCLA1
Species Homo sapiens
Ensembl Gene ENSG00000163541
Encoded Proteins
IDBP-242747
succinate-CoA ligase, alpha subunit
IDBP-381259
succinate-CoA ligase, alpha subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:84423523-84460045
Strand Reverse strand
Band p11.2
Transcripts
ENST00000393868 ENSP00000377446
ENST00000442240 ENSP00000403884
ENST00000430989
ENST00000484365
ENST00000491123
ENST00000487809
ENST00000488234
ENST00000483605
ENST00000491642
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003878 ATP citrate synthase activity
GO:0004775 succinate-CoA ligase (ADP-forming) activity
GO:0004776 succinate-CoA ligase (GDP-forming) activity
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
GO:0048037 cofactor binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006104 succinyl-CoA metabolic process
GO:0006105 succinate metabolic process
GO:0008152 metabolic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0043234 protein complex
GO:0045244 succinate-CoA ligase complex (GDP-forming)
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052738
View Gene Order
ENSBTAG00000006075
Not yet available
Pathways
NETPATH
REACTOME
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00640
Propanoate metabolism pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.270428 Hs.639329
RefSeq NM_003849
HUGO
OMIM
CCDS CCDS1967
HPRD 18128
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca