Version 5.4
Homo sapiens Gene: BRMS1
Summary
InnateDB Gene IDBG-58883.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRMS1
Gene Name breast cancer metastasis suppressor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174744
Encoded Proteins
IDBP-58885
breast cancer metastasis suppressor 1
IDBP-379043
breast cancer metastasis suppressor 1
IDBP-588100
breast cancer metastasis suppressor 1
IDBP-593707
breast cancer metastasis suppressor 1
IDBP-600803
breast cancer metastasis suppressor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66337333-66345125
Strand Reverse strand
Band q13.2
Transcripts
ENST00000359957 ENSP00000353042
ENST00000425825 ENSP00000396052
ENST00000524699 ENSP00000431510
ENST00000530238
ENST00000527375 ENSP00000434591
ENST00000530756 ENSP00000433740
ENST00000534617
ENST00000525127
ENST00000529544
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0009987 cellular process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0090312 positive regulation of protein deacetylation
GO:2000210 positive regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000080268
View Gene Order
ENSBTAG00000017689
Not yet available
Pathways
NETPATH
REACTOME
REACT_228222
HDACs deacetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PPD1
UniProt Splice Variant
Entrez Gene 25855
UniGene
RefSeq NM_001024957 NM_015399
HUGO HGNC:17262
OMIM 606259
CCDS CCDS44654 CCDS8135
HPRD 05879
IMGT
EMBL AP001107
GenPept
RNA Seq Atlas 25855

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca