InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AP2S1

Summary

InnateDB Gene

IDBG-59076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP2S1

Gene Name

adaptor-related protein complex 2, sigma 1 subunit

Synonyms

AP17; CLAPS2; FBH3; FBHOk; HHC3

Species

Homo sapiens

Ensembl Gene

ENSG00000042753

Encoded Proteins

IDBP-59078

adaptor-related protein complex 2, sigma 1 subunit

IDBP-59080

adaptor-related protein complex 2, sigma 1 subunit

IDBP-760161

IDBP-763882

IDBP-765776

IDBP-765266

IDBP-760013

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts. [provided by RefSeq, Jul 2008]
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:46838136-46850992

Strand

Reverse strand

Band

q13.32

Transcripts

ENST00000263270	ENSP00000263270
ENST00000352203	ENSP00000263271
ENST00000599990	ENSP00000471340
ENST00000601498	ENSP00000470176
ENST00000593442	ENSP00000472080
ENST00000597421
ENST00000597020	ENSP00000470235
ENST00000600964
ENST00000601649	ENSP00000470898
ENST00000598027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008565	protein transporter activity

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0015031	protein transport
GO:0016032	viral process
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030100	regulation of endocytosis
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048268	clathrin coat assembly
GO:0050690	regulation of defense response to virus by virus

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030122	AP-2 adaptor complex
GO:0030666	endocytic vesicle membrane
GO:0030669	clathrin-coated endocytic vesicle membrane