Homo sapiens Gene: UNC5A
Summary
InnateDB Gene IDBG-59161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC5A
Gene Name unc-5 homolog A (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000113763
Encoded Proteins
unc-5 homolog A (C. elegans)
unc-5 homolog A (C. elegans)
unc-5 homolog A (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:176810477-176880895
Strand Forward strand
Band q35.2
Transcripts
ENST00000329542 ENSP00000332737
ENST00000513890 ENSP00000424067
ENST00000509580 ENSP00000421795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0033564 anterior/posterior axon guidance
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Role of DCC in regulating apoptosis pathway
Netrin mediated repulsion signals pathway
Netrin-1 signaling pathway
Developmental Biology pathway
Axon guidance pathway
Apoptosis pathway
Regulation of Apoptosis pathway
KEGG
Axon guidance pathway
INOH
PID NCI
Netrin-mediated signaling events
Cross-References
SwissProt Q6ZN44
TrEMBL
UniProt Splice Variant
Entrez Gene 90249
UniGene Hs.33191
RefSeq NM_133369
HUGO HGNC:12567
OMIM 607869
CCDS CCDS34299
HPRD
IMGT
EMBL AB075856 AC027318 AC091897 AC091902 AK131380 BC009333 BC033727 BC157824
GenPept AAH09333 AAI57825 BAB85562 BAD18531
RNA Seq Atlas 90249