Version 5.4
Homo sapiens Gene: WFIKKN2
Summary
InnateDB Gene IDBG-59338.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WFIKKN2
Gene Name WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173714
Encoded Proteins
IDBP-59340
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
IDBP-381798
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:50834650-50842348
Strand Forward strand
Band q21.33
Transcripts
ENST00000311378 ENSP00000311184
ENST00000426127 ENSP00000405889
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008191 metalloendopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0001501 skeletal system development
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010951 negative regulation of endopeptidase activity
GO:0032091 negative regulation of protein binding
GO:0043392 negative regulation of DNA binding
GO:0048747 muscle fiber development
GO:0060021 palate development
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044177
View Gene Order
ENSBTAG00000000731
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.211475
RefSeq NM_175575
HUGO
OMIM
CCDS CCDS11575
HPRD 18303
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca