Version 5.4
Homo sapiens Gene: DHX34
Summary
InnateDB Gene IDBG-59484.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHX34
Gene Name DEAH (Asp-Glu-Ala-His) box polypeptide 34
Synonyms DDX34; HRH1
Species Homo sapiens
Ensembl Gene ENSG00000134815
Encoded Proteins
IDBP-59488
DEAH (Asp-Glu-Ala-His) box polypeptide 34
IDBP-485572
DEAH (Asp-Glu-Ala-His) box polypeptide 34
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:47349281-47382704
Strand Forward strand
Band q13.32
Transcripts
ENST00000328771 ENSP00000331907
ENST00000471451
ENST00000486327
ENST00000460681 ENSP00000418656
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005575 cellular_component
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006019
View Gene Order
ENSBTAG00000006848
Not yet available
Cross-References
SwissProt Q14147
TrEMBL
UniProt Splice Variant
Entrez Gene 9704
UniGene Hs.151706
RefSeq NM_014681 XM_005259443
HUGO HGNC:16719
OMIM 615475
CCDS CCDS12700
HPRD 13144
IMGT
EMBL AC008754 AK297692 D50924
GenPept BAA09483 BAG60050
RNA Seq Atlas 9704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca