Version 5.4
Homo sapiens Gene: SSR1
Summary
InnateDB Gene IDBG-59541.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSR1
Gene Name signal sequence receptor, alpha
Synonyms TRAPA
Species Homo sapiens
Ensembl Gene ENSG00000124783
Encoded Proteins
IDBP-59545
signal sequence receptor, alpha
IDBP-235212
signal sequence receptor, alpha
IDBP-479371
signal sequence receptor, alpha
IDBP-480154
signal sequence receptor, alpha
IDBP-476403
signal sequence receptor, alpha
IDBP-474184
signal sequence receptor, alpha
IDBP-479006
signal sequence receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. [provided by RefSeq, Jul 2008]
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:7268306-7347446
Strand Reverse strand
Band p24.3
Transcripts
ENST00000244763 ENSP00000244763
ENST00000397511 ENSP00000380647
ENST00000474597 ENSP00000418617
ENST00000475213
ENST00000489567 ENSP00000420730
ENST00000479365 ENSP00000417911
ENST00000479485 ENSP00000419953
ENST00000462112 ENSP00000417290
ENST00000488834
ENST00000483409
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0008284 positive regulation of cell proliferation
GO:0010467 gene expression
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021427
View Gene Order
ENSBTAG00000022731
Not yet available
Pathways
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.114033 Hs.639517 Hs.733425 Hs.739946
RefSeq NM_001292008 NM_003144
HUGO
OMIM
CCDS CCDS4499
HPRD 02924
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca