Version 5.4
Homo sapiens Gene: SLC8A2
Summary
InnateDB Gene IDBG-59549.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC8A2
Gene Name solute carrier family 8 (sodium/calcium exchanger), member 2
Synonyms NCX2
Species Homo sapiens
Ensembl Gene ENSG00000118160
Encoded Proteins
IDBP-59551
solute carrier family 8 (sodium/calcium exchanger), member 2
IDBP-590666
solute carrier family 8 (sodium/calcium exchanger), member 2
IDBP-761020
IDBP-764026
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:47428017-47472168
Strand Reverse strand
Band q13.32
Transcripts
ENST00000236877 ENSP00000236877
ENST00000542837 ENSP00000437536
ENST00000539381
ENST00000597014 ENSP00000472208
ENST00000601757
ENST00000594353 ENSP00000472233
ENST00000600576
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005432 calcium:sodium antiporter activity
GO:0005516 calmodulin binding
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007154 cell communication
GO:0007596 blood coagulation
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030376
View Gene Order
ENSBTAG00000010856
Not yet available
Pathways
NETPATH
REACTOME
REACT_23765
Reduction of cytosolic Ca++ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_19320
Sodium/Calcium exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0R211
UniProt Splice Variant
Entrez Gene 6543
UniGene Hs.172884
RefSeq NM_015063 XM_005259172
HUGO HGNC:11069
OMIM 601901
CCDS CCDS33065
HPRD 15990
IMGT
EMBL AC073548
GenPept
RNA Seq Atlas 6543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca