InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KDM3A

Summary

InnateDB Gene

IDBG-59796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM3A

Gene Name

lysine (K)-specific demethylase 3A

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000115548

Encoded Proteins

IDBP-59800

lysine (K)-specific demethylase 3A

IDBP-295339

lysine (K)-specific demethylase 3A

IDBP-295338

lysine (K)-specific demethylase 3A

IDBP-382036

lysine (K)-specific demethylase 3A

IDBP-382062

lysine (K)-specific demethylase 3A

IDBP-382071

lysine (K)-specific demethylase 3A

IDBP-596353

lysine (K)-specific demethylase 3A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:86440647-86492716

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000312912	ENSP00000323659
ENST00000409556	ENSP00000386660
ENST00000409064	ENSP00000386516
ENST00000452034	ENSP00000396561
ENST00000441719	ENSP00000394691
ENST00000427678	ENSP00000397660
ENST00000498528
ENST00000466058
ENST00000463013
ENST00000488971
ENST00000485171
ENST00000462197
ENST00000491383
ENST00000470160
ENST00000483866
ENST00000542128	ENSP00000438324

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0050681	androgen receptor binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0007290	spermatid nucleus elongation
GO:0009755	hormone-mediated signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0033169	histone H3-K9 demethylation
GO:0036123	histone H3-K9 dimethylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046293	formaldehyde biosynthetic process
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000053470

View Gene Order

ENSBTAG00000013580

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.531819 Hs.557425 Hs.665536

RefSeq

NM_001146688 NM_018433 XM_006712051

HUGO

OMIM

CCDS

CCDS1990

HPRD

11054

IMGT

EMBL

GenPept

RNA Seq Atlas