InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP5I

Summary

InnateDB Gene

IDBG-5992.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5I

Gene Name

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E

Synonyms

ATP5K

Species

Homo sapiens

Ensembl Gene

ENSG00000169020

Encoded Proteins

IDBP-5996

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:672436-674338

Strand

Reverse strand

Band

p16.3

Transcripts

ENST00000304312	ENSP00000306003
ENST00000515202
ENST00000506525
ENST00000505852
ENST00000515116

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006200	ATP catabolic process
GO:0015986	ATP synthesis coupled proton transport
GO:0022904	respiratory electron transport chain
GO:0042776	mitochondrial ATP synthesis coupled proton transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0046034	ATP metabolic process

Cellular Component

GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000050856

View Gene Order

ENSBTAG00000017496

Not yet available

Pathways

NETPATH

REACTOME

REACT_6759

Formation of ATP by chemiosmotic coupling pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa00190

Oxidative phosphorylation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_007100

HUGO

OMIM

CCDS

CCDS3337

HPRD

03308

IMGT

EMBL

GenPept

RNA Seq Atlas