Version 5.4
Homo sapiens Gene: HLF
Summary
InnateDB Gene IDBG-60021.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLF
Gene Name hepatic leukemia factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108924
Encoded Proteins
IDBP-60023
hepatic leukemia factor
IDBP-382042
hepatic leukemia factor
IDBP-764608
IDBP-762714
IDBP-760620
IDBP-759686
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:55265012-55325065
Strand Forward strand
Band q22
Transcripts
ENST00000226067 ENSP00000226067
ENST00000430986 ENSP00000402496
ENST00000575868
ENST00000572234
ENST00000575345 ENSP00000460572
ENST00000570962 ENSP00000460265
ENST00000572002 ENSP00000461455
ENST00000575307
ENST00000573020
ENST00000573945 ENSP00000460296
ENST00000573422
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0035914 skeletal muscle cell differentiation
GO:0048511 rhythmic process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003949
View Gene Order
ENSBTAG00000006618
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.196952 Hs.611966 Hs.735805
RefSeq NM_002126 XM_005257269
HUGO
OMIM
CCDS CCDS11585
HPRD 00797
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca