Version 5.4
Homo sapiens Gene: CD8B
Summary
InnateDB Gene IDBG-60041.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD8B
Gene Name CD8b molecule
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172116
Encoded Proteins
IDBP-60043
CD8b molecule
IDBP-60045
CD8b molecule
IDBP-60049
CD8b molecule
IDBP-242963
CD8b molecule
IDBP-242965
CD8b molecule
IDBP-382132
CD8b molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:86815339-86861924
Strand Reverse strand
Band p11.2
Transcripts
ENST00000331469 ENSP00000331172
ENST00000349455 ENSP00000340592
ENST00000390655 ENSP00000375070
ENST00000393761 ENSP00000377358
ENST00000393759 ENSP00000377356
ENST00000431506 ENSP00000394806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015026 coreceptor activity
GO:0042288 MHC class I protein binding
Biological Process
GO:0006955 immune response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016032 viral process
GO:0042110 T cell activation
GO:0050690 regulation of defense response to virus by virus
GO:0050776 regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0031901 early endosome membrane
GO:0042101 T cell receptor complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_11200
Nef Mediated CD8 Down-regulation pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04612
Antigen processing and presentation pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05340
Primary immunodeficiency pathway
INOH
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
Cross-References
SwissProt P10966
TrEMBL B4E0F8 B4E0Z8 Q8TD28
UniProt Splice Variant
Entrez Gene 926
UniGene Hs.534308
RefSeq NM_001178100 NM_004931 NM_172101 NM_172102 NM_172213
HUGO HGNC:1707
OMIM 186730
CCDS CCDS1994 CCDS1995 CCDS1997 CCDS42708 CCDS54376
HPRD
IMGT
EMBL AC111200 AK303360 AK303595 AY032722 BC100911 BC100912 BC100913 BC100914 M36712 S55730 S55731 S55733 S87068 S87070 S87073 S87078 S87081 S87083 S87087 S87090 X13444 X13445 X13446 X13452 Y00805
GenPept AAA35664 AAB21669 AAB21670 AAB21671 AAB21672 AAD13877 AAI00912 AAI00913 AAI00914 AAI00915 AAK91557 BAG64420 BAG64610 CAA31795 CAA31796 CAA31797 CAA31803 CAA68750
RNA Seq Atlas 100996919 926

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca