InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBA1

Summary

InnateDB Gene

IDBG-60053.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA1

Gene Name

ubiquitin-like modifier activating enzyme 1

Synonyms

A1S9; A1S9T; A1ST; AMCX1; CFAP124; GXP1; POC20; SMAX2; UBA1A; UBE1; UBE1X

Species

Homo sapiens

Ensembl Gene

ENSG00000130985

Encoded Proteins

IDBP-60055

ubiquitin-like modifier activating enzyme 1

IDBP-60057

ubiquitin-like modifier activating enzyme 1

IDBP-60061

ubiquitin-like modifier activating enzyme 1

IDBP-369069

ubiquitin-like modifier activating enzyme 1

IDBP-369071

ubiquitin-like modifier activating enzyme 1

IDBP-369077

ubiquitin-like modifier activating enzyme 1

IDBP-369082

ubiquitin-like modifier activating enzyme 1

IDBP-369090

ubiquitin-like modifier activating enzyme 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:47190861-47215128

Strand

Forward strand

Band

p11.3

Transcripts

ENST00000377351	ENSP00000366568
ENST00000335972	ENSP00000338413
ENST00000377269	ENSP00000366481
ENST00000412206	ENSP00000415033
ENST00000427561	ENSP00000397816
ENST00000442035	ENSP00000389583
ENST00000457753	ENSP00000404796
ENST00000451702	ENSP00000401101
ENST00000490869

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 177 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	177 [view]
Protein-Protein	176 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004839	ubiquitin activating enzyme activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006974	cellular response to DNA damage stimulus
GO:0008152	metabolic process
GO:0008219	cell death
GO:0016567	protein ubiquitination
GO:0019941	modification-dependent protein catabolic process

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0030057	desmosome
GO:0030867	rough endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001924

View Gene Order

ENSBTAG00000016764

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

hsa05012

Parkinson's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.533273

RefSeq

NM_003334 NM_153280 XM_005272648 XM_005272649 XM_005272650

HUGO

OMIM

CCDS

CCDS14275

HPRD

02440

IMGT

EMBL

GenPept

RNA Seq Atlas