Version 5.4
Homo sapiens Gene: PLSCR2
Summary
InnateDB Gene IDBG-60151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLSCR2
Gene Name phospholipid scramblase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163746
Encoded Proteins
IDBP-60153
phospholipid scramblase 2
IDBP-476287
phospholipid scramblase 2
IDBP-477360
phospholipid scramblase 2
IDBP-477902
phospholipid scramblase 2
IDBP-806448
phospholipid scramblase 2
IDBP-806451
phospholipid scramblase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:146391421-146495991
Strand Reverse strand
Band q24
Transcripts
ENST00000336685 ENSP00000338707
ENST00000463633 ENSP00000419669
ENST00000497985 ENSP00000420132
ENST00000489015 ENSP00000418444
ENST00000474418
ENST00000613069 ENSP00000478902
ENST00000610787 ENSP00000478044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0017128 phospholipid scramblase activity
Biological Process
GO:0017121 phospholipid scrambling
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL C9J636
UniProt Splice Variant
Entrez Gene 57047
UniGene Hs.177968
RefSeq NM_001199978 NM_001199979 NM_020359
HUGO HGNC:16494
OMIM 607610
CCDS CCDS3134 CCDS56284 CCDS75029
HPRD 09621
IMGT
EMBL AC069528
GenPept
RNA Seq Atlas 57047

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca