InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DCTN3

Summary

InnateDB Gene

IDBG-60175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCTN3

Gene Name

dynactin 3 (p22)

Synonyms

DCTN-22; DCTN22

Species

Homo sapiens

Ensembl Gene

ENSG00000137100

Encoded Proteins

IDBP-60177

dynactin 3 (p22)

IDBP-60179

dynactin 3 (p22)

IDBP-60181

dynactin 3 (p22)

IDBP-60185

dynactin 3 (p22)

IDBP-60187

dynactin 3 (p22)

IDBP-367631

dynactin 3 (p22)

IDBP-597307

dynactin 3 (p22)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:34613545-34620523

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000259632	ENSP00000259632
ENST00000378916	ENSP00000368196
ENST00000341694	ENSP00000343986
ENST00000378913	ENSP00000368193
ENST00000378911	ENSP00000368191
ENST00000421919	ENSP00000390842
ENST00000472418
ENST00000479399
ENST00000477738	ENSP00000432915
ENST00000481438
ENST00000472074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0007017	microtubule-based process
GO:0007067	mitotic nuclear division
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005869	dynactin complex
GO:0005875	microtubule associated complex
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0048471	perinuclear region of cytoplasm