Version 5.4
Homo sapiens Gene: CARNS1
Summary
InnateDB Gene IDBG-60298.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARNS1
Gene Name carnosine synthase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172508
Encoded Proteins
IDBP-60300
carnosine synthase 1
IDBP-379431
carnosine synthase 1
IDBP-585388
carnosine synthase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CARNS1 (EC 6.3.2.11), a member of the ATP-grasp family of ATPases, catalyzes the formation of carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine), which are found mainly in skeletal muscle and the central nervous system, respectively (Drozak et al., 2010 [PubMed 20097752]).[supplied by OMIM, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67414968-67425607
Strand Forward strand
Band q13.2
Transcripts
ENST00000307823 ENSP00000308268
ENST00000445895 ENSP00000389009
ENST00000525907
ENST00000529925
ENST00000531040 ENSP00000431670
ENST00000531958
ENST00000531388
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0046872 metal ion binding
GO:0047730 carnosine synthase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0035499 carnosine biosynthetic process
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000075289
View Gene Order
ENSBTAG00000017690
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00340
Histidine metabolism pathway
hsa00330
Arginine and proline metabolism pathway
hsa00410
beta-Alanine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502982
RefSeq NM_001166222 NM_020811 XM_005274125
HUGO
OMIM
CCDS CCDS44658 CCDS53667
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca