Version 5.4
Homo sapiens Gene: SLC35B3
Summary
InnateDB Gene IDBG-60332.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC35B3
Gene Name solute carrier family 35, member B3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124786
Encoded Proteins
IDBP-60334
solute carrier family 35, member B3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sulfation of a variety of molecules, including glycoproteins, proteoglycans, and glycolipids, requires 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS), a high-energy form of the universal sulfate donor. SLC35B3 translocates PAPS from the cytosol or nucleus, where it is synthesized, to the Golgi lumen for use (Kamiyama et al., 2006 [PubMed 16492677]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:8413068-8435483
Strand Reverse strand
Band p24.3
Transcripts
ENST00000379660 ENSP00000368981
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006805 xenobiotic metabolic process
GO:0030203 glycosaminoglycan metabolic process
GO:0044281 small molecule metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO:0055085 transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021432
View Gene Order
ENSBTAG00000009157
Not yet available
Pathways
NETPATH
REACTOME
REACT_22151
Transport of nucleotide sugars pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_6840
Transport and synthesis of PAPS pathway
REACT_6913
Cytosolic sulfonation of small molecules pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_6959
Phase II conjugation pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9H1N7
TrEMBL A0A024QZW4 A0A024R008
UniProt Splice Variant
Entrez Gene 51000
UniGene Hs.285847
RefSeq NM_001142541 NM_015948 XM_005249157 XM_006715102
HUGO HGNC:21601
OMIM 610845
CCDS CCDS4508
HPRD
IMGT
EMBL AB231931 AF132953 AL355815 BC006973 BX538271 BX641086 CH471087
GenPept AAD27728 AAH06973 BAE93015 CAC19504 CAD98078 CAE46041 EAW55234 EAW55235 EAW55236 EAW55239
RNA Seq Atlas 51000

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca