Version 5.4
Homo sapiens Gene: DOK3
Summary
InnateDB Gene IDBG-60370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK3
Gene Name docking protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000146094
Encoded Proteins
IDBP-60372
docking protein 3
IDBP-60374
docking protein 3
IDBP-60376
docking protein 3
IDBP-476804
docking protein 3
IDBP-482975
docking protein 3
IDBP-482191
docking protein 3
IDBP-475051
docking protein 3
IDBP-485490
docking protein 3
IDBP-483689
docking protein 3
IDBP-485489
docking protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22761938
DOK3 is a negative regulator of TLR signalling by limiting LPS-induced ERK activation and cytokine responses in macrophages. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22761938
[Mus musculus] Dok3 is a negative regulator of TLR signalling by limiting LPS-induced ERK activation and cytokine responses in macrophages.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177501907-177511274
Strand Reverse strand
Band q35.3
Transcripts
ENST00000312943 ENSP00000325174
ENST00000377112 ENSP00000366316
ENST00000357198 ENSP00000349727
ENST00000500323
ENST00000501403 ENSP00000421688
ENST00000510380 ENSP00000422395
ENST00000506493 ENSP00000423328
ENST00000502885 ENSP00000423635
ENST00000510898 ENSP00000424726
ENST00000509310 ENSP00000424580
ENST00000502380
ENST00000512660
ENST00000510389 ENSP00000426694
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035711
View Gene Order
ENSBTAG00000025401
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
NetPath_12
BCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6R951 D6R977 D6RAM3 D6RAV2 D6RAZ9 D6RC22
UniProt Splice Variant
Entrez Gene 79930
UniGene Hs.720849
RefSeq NM_001144875 NM_001144876 NM_024872 XM_005265984 XM_005265985 XM_005265987 XM_006714920
HUGO HGNC:24583
OMIM 611435
CCDS CCDS4426 CCDS47349 CCDS47350
HPRD 16834
IMGT
EMBL AC145098
GenPept
RNA Seq Atlas 79930

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca