Version 5.4
Homo sapiens Gene: NEBL
Summary
InnateDB Gene IDBG-60402.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEBL
Gene Name nebulette
Synonyms LASP2; LNEBL
Species Homo sapiens
Ensembl Gene ENSG00000078114
Encoded Proteins
IDBP-60406
nebulette
IDBP-60410
nebulette
IDBP-60412
nebulette
IDBP-368717
nebulette
IDBP-368756
nebulette
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:20779973-21174187
Strand Reverse strand
Band p12.31
Transcripts
ENST00000377159 ENSP00000366364
ENST00000377122 ENSP00000366326
ENST00000377119 ENSP00000366323
ENST00000417816 ENSP00000393896
ENST00000434381 ENSP00000396512
ENST00000493005
ENST00000473616
ENST00000492325
ENST00000460652
ENST00000481592
ENST00000498424
ENST00000482754
ENST00000485750
ENST00000464278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005523 tropomyosin binding
GO:0008092 cytoskeletal protein binding
GO:0008270 zinc ion binding
GO:0008307 structural constituent of muscle
GO:0031005 filamin binding
GO:0051015 actin filament binding
Biological Process
GO:0071691 cardiac muscle thin filament assembly
Cellular Component
GO:0001725 stress fiber
GO:0030018 Z disc
GO:0031674 I band
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053702
View Gene Order
ENSBTAG00000013339
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.5025 Hs.609027
RefSeq NM_001173484 NM_006393 NM_213569 XM_005252342
HUGO
OMIM
CCDS CCDS7133 CCDS7134
HPRD 10403
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca