Version 5.4
Homo sapiens Gene: PLA2G1B
Summary
InnateDB Gene IDBG-60467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G1B
Gene Name phospholipase A2, group IB (pancreas)
Synonyms PLA2; PLA2A; PPLA2
Species Homo sapiens
Ensembl Gene ENSG00000170890
Encoded Proteins
IDBP-60469
phospholipase A2, group IB (pancreas)
IDBP-384148
phospholipase A2, group IB (pancreas)
IDBP-596373
phospholipase A2, group IB (pancreas)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM, Mar 2008]
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:120322111-120327789
Strand Reverse strand
Band q24.31
Transcripts
ENST00000308366 ENSP00000312286
ENST00000423423 ENSP00000413594
ENST00000549767 ENSP00000447233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005102 receptor binding
GO:0005509 calcium ion binding
GO:0032052 bile acid binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0002227 innate immune response in mucosa
GO:0002446 neutrophil mediated immunity
GO:0006633 fatty acid biosynthetic process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0015758 glucose transport
GO:0016042 lipid catabolic process
GO:0019370 leukotriene biosynthetic process
GO:0019731 antibacterial humoral response
GO:0030593 neutrophil chemotaxis
GO:0032431 activation of phospholipase A2 activity
GO:0032637 interleukin-8 production
GO:0032869 cellular response to insulin stimulus
GO:0035556 intracellular signal transduction
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044240 multicellular organismal lipid catabolic process
GO:0044281 small molecule metabolic process
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046470 phosphatidylcholine metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0050482 arachidonic acid secretion
GO:0050714 positive regulation of protein secretion
GO:0050778 positive regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0030141 secretory granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029522
View Gene Order
ENSBTAG00000026732
Not yet available
Pathways
NETPATH
REACTOME
REACT_120829
Acyl chain remodelling of PC pathway
REACT_120722
Acyl chain remodelling of PI pathway
REACT_121384
Acyl chain remodelling of PS pathway
REACT_120906
Synthesis of PA pathway
REACT_121324
Acyl chain remodelling of PG pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa00590
Arachidonic acid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04975
Fat digestion and absorption pathway
hsa04972
Pancreatic secretion pathway
INOH
PID NCI
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000928
HUGO
OMIM
CCDS CCDS9195
HPRD 01396
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca