Version 5.4
| Homo sapiens Gene: DEFA4 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-6052.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | DEFA4 | ||||||||||||||||||
| Gene Name | defensin, alpha 4, corticostatin | ||||||||||||||||||
| Synonyms | DEF4; HNP-4; HP-4; HP4 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000164821 | ||||||||||||||||||
| Encoded Proteins |
defensin, alpha 4, corticostatin
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
DEFA4 along with DEFA1 and DEFA3 are cationic alpha-defensin peptides that have multiple functions in the immune system.
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| Entrez Gene | |||||||||||||||||||
| Summary |
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Jul 2008] Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 8:6935822-6938338 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p23.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Alpha-defensins pathway
Defensins pathway
Innate Immune System pathway
Immune System pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P12838 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 1669 | ||||||||||||||||||
| UniGene | Hs.591391 | ||||||||||||||||||
| RefSeq | NM_001925 | ||||||||||||||||||
| HUGO | HGNC:2763 | ||||||||||||||||||
| OMIM | 601157 | ||||||||||||||||||
| CCDS | CCDS5961 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF200455 BC093959 BC106747 BC112091 CH471153 U18745 X65977 | ||||||||||||||||||
| GenPept | AAA64488 AAH93959 AAI06748 AAI12092 AAT68877 CAA46792 EAW80486 | ||||||||||||||||||
| RNA Seq Atlas | 1669 | ||||||||||||||||||