Version 5.4
Homo sapiens Gene: WWTR1
Summary
InnateDB Gene IDBG-60802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WWTR1
Gene Name WW domain containing transcription regulator 1
Synonyms TAZ
Species Homo sapiens
Ensembl Gene ENSG00000018408
Encoded Proteins
IDBP-60804
WW domain containing transcription regulator 1
IDBP-480047
WW domain containing transcription regulator 1
IDBP-478708
WW domain containing transcription regulator 1
IDBP-477073
WW domain containing transcription regulator 1
IDBP-482217
WW domain containing transcription regulator 1
IDBP-481303
WW domain containing transcription regulator 1
IDBP-483258
WW domain containing transcription regulator 1
IDBP-477090
WW domain containing transcription regulator 1
IDBP-476114
WW domain containing transcription regulator 1
IDBP-478624
WW domain containing transcription regulator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:149517235-149736714
Strand Reverse strand
Band q25.1
Transcripts
ENST00000360632 ENSP00000353847
ENST00000465804 ENSP00000419465
ENST00000467467 ENSP00000419234
ENST00000471586 ENSP00000418621
ENST00000494754 ENSP00000417862
ENST00000472417 ENSP00000417339
ENST00000485244
ENST00000479238 ENSP00000418580
ENST00000485352 ENSP00000420120
ENST00000475579 ENSP00000420159
ENST00000460517 ENSP00000417984
ENST00000474080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0001933 negative regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006469 negative regulation of protein kinase activity
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010467 gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0017145 stem cell division
GO:0032835 glomerulus development
GO:0035329 hippo signaling
GO:0035414 negative regulation of catenin import into nucleus
GO:0045599 negative regulation of fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060271 cilium morphogenesis
GO:0060390 regulation of SMAD protein import into nucleus
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027803
View Gene Order
ENSBTAG00000007814
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_118607
Signaling by Hippo pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_111217
Metabolism pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9GZV5
TrEMBL C9J038 C9J337 C9J588 C9JQS8 C9JR84
UniProt Splice Variant
Entrez Gene 25937
UniGene Hs.535002 Hs.594912 Hs.743486
RefSeq NM_001168278 NM_001168280 NM_015472
HUGO HGNC:24042
OMIM 607392
CCDS CCDS3144
HPRD
IMGT
EMBL AC012014 AC069216 AC108672 AJ299431 AK022036 AL050107 AL833852 BC014052 CH471052
GenPept AAH14052 BAB13957 CAB43275 CAC17722 CAD38711 EAW78868 EAW78869
RNA Seq Atlas 25937

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca