Version 5.4
Homo sapiens Gene: USP11
Summary
InnateDB Gene IDBG-61044.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP11
Gene Name ubiquitin specific peptidase 11
Synonyms UHX1
Species Homo sapiens
Ensembl Gene ENSG00000102226
Encoded Proteins
IDBP-61046
ubiquitin specific peptidase 11
IDBP-61048
ubiquitin specific peptidase 11
IDBP-61050
ubiquitin specific peptidase 11
IDBP-61052
ubiquitin specific peptidase 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:47232690-47248328
Strand Forward strand
Band p11.3
Transcripts
ENST00000218348 ENSP00000218348
ENST00000377107 ENSP00000366311
ENST00000377080 ENSP00000366282
ENST00000377078 ENSP00000366279
ENST00000478596
ENST00000469080
ENST00000489111
ENST00000489030
ENST00000480104
ENST00000488848
ENST00000497179
ENST00000467378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 131 experimentally validated interaction(s) in this database.
Experimentally validated
Total 131 [view]
Protein-Protein 129 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031066
View Gene Order
ENSBTAG00000016772
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_16907
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.171501
RefSeq NM_004651 XM_005272674
HUGO
OMIM
CCDS CCDS14277
HPRD 02081
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca