InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RNF43

Summary

InnateDB Gene

IDBG-61124.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF43

Gene Name

ring finger protein 43

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000108375

Encoded Proteins

IDBP-294218

ring finger protein 43

IDBP-758350

IDBP-759777

IDBP-759622

IDBP-762879

IDBP-759706

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

RNF43 is a HAP95 (AKAP8L; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004 [PubMed 15492824]; Sugiura et al., 2008 [PubMed 18313049]).[supplied by OMIM, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:58352500-58417595

Strand

Reverse strand

Band

q22

Transcripts

ENST00000407977	ENSP00000385328
ENST00000581868	ENSP00000462447
ENST00000582293
ENST00000580014
ENST00000577716	ENSP00000462764
ENST00000584437	ENSP00000463069
ENST00000583753	ENSP00000462502
ENST00000577625	ENSP00000463716

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0016055	Wnt signaling pathway
GO:0016567	protein ubiquitination
GO:0030178	negative regulation of Wnt signaling pathway
GO:0038018	Wnt receptor catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072089	stem cell proliferation